A basic understanding of botanical remedies is that herbs contain many active ingredients, and that primary active ingredients are positively effected by the synergy of secondary compounds. In other words, the whole is better than any of the individual parts.
In this abstract, the authors state that according to their literature review, there is good evidence that the secondary compounds in marijuana enhance the beneficial effects of THC.
In fact, they state that not only do the additional marijuana components decrease some of the negative effects of THC, but that they may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity.
It seems that a good recommendation is to use this natural medicine in its natural whole plant form.